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When Yamaguchi began to pursue medical education at the University of California, San Francisco, in 1971, she realized how her lack of exposure to professional role models, as well as her experience of growing up in an extremely \"non-verbal\" family, made it a challenge for her to be in a decision-making position. She describes herself as being only \"around on the fringes\" of the Asian American activism in the 1970s. She joined the East Bay Socialist Doctors Group and the Physicians for Social Responsibility, and through members of these groups, she learned in the early 1980s about US survivors of the Hiroshima and Nagasaki bombings. She was struck by their graciousness and gratefulness to physicians who offered the needed medical care. \"Given what they've gone through,\" Yamaguchi says, she felt it necessary to assist US hibakusha. 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